Massimo Lopes Selected Research

Chromosome Breakage

1/2020	CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage.
1/2018	ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links.
3/2015	Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells.
3/2015	Poly(ADP-ribosyl) glycohydrolase prevents the accumulation of unusual replication structures during unperturbed S phase.
12/2013	Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template.
3/2012	Topoisomerase I poisoning results in PARP-mediated replication fork reversal.

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Massimo Lopes Research Topics

Disease

11	Neoplasms (Cancer) 01/2022 - 03/2012
6	Chromosome Breakage 01/2020 - 03/2012
3	Ataxia Telangiectasia (Louis Bar Syndrome) 02/2016 - 09/2011
2	Carcinogenesis 10/2020 - 01/2020
2	Poisoning 03/2015 - 03/2012
1	Fanconi Anemia (Fanconi's Anemia) 01/2021
1	Hypersensitivity (Allergy) 01/2018
1	Liver Neoplasms (Liver Cancer) 11/2017
1	Liver Diseases (Liver Disease) 11/2017
1	Hepatocellular Carcinoma (Hepatoma) 11/2017
1	Chromosomal Instability (Chromosome Stability) 01/2014
1	Infections 09/2011
1	Genomic Instability 02/2005

Drug/Important Bio-Agent (IBA)

6	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 09/2011
2	CamptothecinIBA 04/2016 - 03/2012
2	Type I DNA Topoisomerases (Topoisomerase I)IBA 04/2016 - 03/2012
2	ChromatinIBA 02/2016 - 03/2015
2	Histones (Histone)IBA 01/2014 - 09/2011
2	Proteins (Proteins, Gene)FDA Link 03/2012 - 09/2011
1	Oncogene Proteins (Oncogene Protein)IBA 01/2022
1	Phosphotransferases (Kinase)IBA 01/2020
1	Glycoside Hydrolases (Endoglycosidases)IBA 11/2018
1	Poly Adenosine Diphosphate RiboseIBA 11/2018
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2018
1	Caspase 8 (Caspase-8)IBA 11/2017
1	clonidine-displacing substance (ClDS)IBA 11/2017
1	Topoisomerase I InhibitorsIBA 04/2016
1	Carrier Proteins (Binding Protein)IBA 02/2016
1	PoisonsIBA 03/2015
1	Nucleic Acid Synthesis InhibitorsIBA 03/2015
1	RecQ HelicasesIBA 02/2005

Therapy/Procedure

5	Drug Therapy (Chemotherapy) 01/2020 - 03/2015
3	Therapeutics 10/2020 - 04/2015